abstract：:The biodistributions of carborane-containing copper porphyrins, CuTCP and CuTCPH, have been studied previously in mice bearing subcutaneously implanted mammary carcinomas. We now report biodistributions of those porphyrins in Fischer 344 rats bearing intracranial and/or multiple subcutaneous isogeneic 9L gliosarcomas ...

journal_title：Journal of neuro-oncology

authors： Miura M,Joel DD,Smilowitz HM,Nawrocky MM,Micca PL,Hoch DA,Coderre JA,Slatkin DN

更新日期：2001-04-01 00:00:00

abstract：:Most tumors, including gliomas, are resistant to tumor necrosis factor (TNF) cytotoxicity unless protein or RNA synthesis is inhibited. We investigated the effects of the combined use of TNF-alpha and cisplatin (CDDP) on cultured malignant glioma cells, T98G, U373MG, A172, and U87MG. All glioma cell lines were sensiti...

journal_title：Journal of neuro-oncology

authors： Duan L,Aoyagi M,Tamaki M,Nakagawa K,Nagashima G,Nagasaka Y,Ohno K,Yamamoto K,Hirakawa K

更新日期：2001-03-01 00:00:00

abstract：:Intravascular lymphomatosis (IL) is a rare entity only recently included in lymphoma classification, whose main feature is the exclusive or predominant growth of neoplastic cells within blood vessels. The vast majority of the patients affected by IL belong to the 7th or 8th decade of life and present with skin rash or...

journal_title：Journal of neuro-oncology

authors： Massimino M,Giardini R,Cefalo G,Simonetti F,Pollo B,Giombini S,Tesoro-Tess JD,Ponzoni M,Patriarca C

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:Feasibility, antitumor activity and toxicity of accelerated hyperfractionated radiation therapy (Acc Hfx RT) and concurrent carboplatin/etoposide (CBDCA/VP 16) chemotherapy were investigated in patients with malignant glioma. MATERIAL AND METHODS:Seventy-nine patients with either glioblastoma multiforme (GBM) ...

journal_title：Journal of neuro-oncology

authors： Jeremic B,Shibamoto Y,Grujicic D,Stojanovic M,Milicic B,Nikolic N,Dagovic A,Aleksandrovic J

更新日期：2001-01-01 00:00:00

abstract：:After chromosome 22 and NF2 inactivation, the loss of chromosome 1p is one of the most frequent abnormalities encountered in meningiomas. However the putative tumor suppressor gene located on 1p inactivated in meningiomas has still to be identified. We screened 68 meningiomas for LOH on chromosome 22 and 1. We found 3...

journal_title：Journal of neuro-oncology

authors： Leuraud P,Marie Y,Robin E,Huguet S,He J,Mokhtari K,Cornu P,Hoang-Xuan K,Sanson M

更新日期：2000-12-01 00:00:00

abstract：:Two distinct mechanisms, vasculogenesis and angiogenesis implement the formation of the vascular network in the embryo. Vasculogenesis gives rise to the heart and the first primitive vascular plexus inside the embryo and in its surrounding membranes, as the yolk sac circulation. Angiogenesis is responsible for the rem...

journal_title：Journal of neuro-oncology

authors： Patan S

更新日期：2000-10-01 00:00:00

abstract：:Angiogenesis, the formation of blood vessels from a pre-existing vasculature, is a process whereby capillary sprouts are formed in response to externally supplied chemical stimuli. The sprouts then grow and develop, driven initially by endothelial cell migration, and organize themselves into a branched, connected netw...

journal_title：Journal of neuro-oncology

authors： Chaplain MA

更新日期：2000-10-01 00:00:00

abstract：:Twenty-eight patients who were previously treated by aggressive surgery and radiation and were diagnosed with supratentorial malignant gliomas received a combination of nimustine hydrochloride; 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU), cisplatin and etoposide (ACE ...

journal_title：Journal of neuro-oncology

authors： Beppu T,Yoshida Y,Arai H,Wada T,Suzuki M,Ogawa A,Hakozaki S,Kubo N

更新日期：2000-09-01 00:00:00

abstract：:A historically controlled phase II study was undertaken to investigate the efficacy and toxicity of a postoperative treatment consisting of high-dose continuous tamoxifen, carboplatin and radiotherapy in patients with newly diagnosed glioblastoma. Between 1995 and 1998, 50 patients with newly diagnosed glioblastomas u...

journal_title：Journal of neuro-oncology

authors： Puchner MJ,Herrmann HD,Berger J,Cristante L

更新日期：2000-09-01 00:00:00

abstract：:One objection to using cell cultures for studying the proliferation of tumors is the potential for phenotypic changes that may occur in vitro. Here, we compared the antigen pattern expression of cultured meningioma cells with that of the primary tumor. Cell cultures established from 9 intracranial meningiomas and depa...

journal_title：Journal of neuro-oncology

authors： Pallini R,Casalbore P,Mercanti D,Maggiano N,Larocca LM

更新日期：2000-08-01 00:00:00

abstract：:The antiproliferative effect of IFNalpha was tested on the human glioblastoma cell lines, U-373MG and T98G. IFNalpha significantly inhibited the growth of both cell lines, but was more effective in retarding the growth of U-373MG cells. Flow cytometry analysis indicated that synchronized IFNalpha-treated U-373MG cells...

journal_title：Journal of neuro-oncology

authors： Tanabe T,Kominsky SL,Subramaniam PS,Johnson HM,Torres BA

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:Atypical and malignant meningiomas are at high risk for local failure. The role of radiation therapy (RT) and dose levels required to improve tumor control are poorly defined. This study reviews our experience with RT. MATERIAL AND METHODS:Thirty-one patients underwent fractionated RT for atypical (AM, 15 pa...

journal_title：Journal of neuro-oncology

authors： Hug EB,Devries A,Thornton AF,Munzenride JE,Pardo FS,Hedley-Whyte ET,Bussiere MR,Ojemann R

更新日期：2000-06-01 00:00:00

abstract：:The use of radiation therapy in the management of intramedullary spinal cord tumors remains controversial. Several studies indicate that the use of postoperative radiation therapy modestly improves both local control and survival in spinal cord ependymomas and astrocytomas. Modern treatment planning and imaging allow ...

journal_title：Journal of neuro-oncology

authors： Isaacson SR

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The postoperative cerebellar mutism syndrome (CMS) is an unique acute postoperative complication characterized by transient decrease in speech output (often mutism), apathy, irritability as well as global cerebellar dysfunction. As much as 25% of patients undergoing a resection of a cerebellar...

journal_title：Journal of neuro-oncology

authors： Siffert J,Poussaint TY,Goumnerova LC,Scott RM,LaValley B,Tarbell NJ,Pomeroy SL

更新日期：2000-05-01 00:00:00

abstract：:Meningiomas may display benign (Grade I), atypical (Grade II) and anaplastic (Grade III) histopathological findings. The cytogenetic studies strongly suggest that secondary changes (moreover loss of chromosome 22) appear to be associated with more atypical features and with greater clinical aggressivity. We studied 60...

journal_title：Journal of neuro-oncology

authors： Cerdá-Nicolás M,López-Gineś C,Pérez-Bacete M,Barcia-Salorio JL,Llombart-Bosch A

更新日期：2000-04-01 00:00:00

abstract：:Intracranial pseudolymphoma is a rare tumor of the central nervous system. A 35-year-old woman presented with a frontal subcutaneous tumor. Magnetic resonance imaging revealed a left frontal meningeal tumor involving subcutaneous tissue without bone involvement. The mass was completely removed and the histological asp...

journal_title：Journal of neuro-oncology

authors： Donnet A,Horschowski N,Dufour H,Figarella-Branger D,Bryon PA,Berger F,Harle JR,Grisoli F

更新日期：2000-04-01 00:00:00

abstract：:A thirty-year-old male with an intracranial malignant meningioma, first diagnosed 9 years ago, with three recurrences was admitted with a hypoglycemic shock. The blood glucose level was 17 mg/dl, requiring treatment with high doses of intravenous and oral dextrose for improvement. A large metastatic tumor in the liver...

journal_title：Journal of neuro-oncology

authors： Yoshida D,Sugisaki Y,Tamaki T,Saitoh N,Node Y,Shimura T,Teramoto A

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:To compare chemotherapy treatment monitoring in astrocytoma by 201thallium single photon emission computed tomography (SPECT) and photon magnetic resonance spectroscopy (1H-MRS) with magnetic resonance imaging (MRI), and to evaluate the influence of morphological tumor changes on cerebral 201thallium uptake and...

journal_title：Journal of neuro-oncology

authors： Kallén K,Burtscher IM,Holtås S,Ryding E,Rosén I

更新日期：2000-01-01 00:00:00

abstract：:The relationship between coagulation cascade activation and glioma cell proliferation was examined. The human glioma cell lines T98G, TM-1 and normal human astrocyte cell strain (NHA) were examined. Using anti-tissue factor (TF) antibody, immunocytochemical detection of TF antigen was obtained in both cell lines and c...

journal_title：Journal of neuro-oncology

authors： Ogiichi T,Hirashima Y,Nakamura S,Endo S,Kurimoto M,Takaku A

更新日期：2000-01-01 00:00:00

abstract：:To evaluate whether vigorous treatment is beneficial for patients with meningeal gliomatosis (MG) we reviewed the case records of 20 consecutive patients treated for a symptomatic MG in our center. All received systemic or intrathecal chemotherapy and six received additional cranial or spinal radiotherapy. Six patient...

journal_title：Journal of neuro-oncology

authors： Pradat PF,Hoang-Xuan K,Cornu P,Mokhtari K,Martin-Duverneuil N,Poisson M,Delattre JY

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:In most patients with recurrent glioma chemotherapy is the only remaining treatment option. In general results of chemotherapy in these patients are poor, and trials on new regimens are indicated. Because relatively good results have been achieved with combinations of platin compounds and etoposide, we inves...

journal_title：Journal of neuro-oncology

authors： van den Bent MJ,Pronk L,Sillevis Smitt PA,Vecht CJ,Eskens FA,Verweij J

更新日期：1999-08-01 00:00:00

abstract：:The use of radiotherapy alone to treat primary central nervous system lymphoma (PCNSL) does not produce the high local control and survival rates that it does in limited extranodal non-Hodgkin's lymphoma outside the central nervous system (CNS). Even with doses of whole brain radiation therapy (WBRT) to 40+20 Gy boost...

journal_title：Journal of neuro-oncology

authors： Nelson DF

更新日期：1999-07-01 00:00:00

abstract：:We report results of a conservative treatment for brain metastases from malignant melanoma with a combination of irradiation and chemotherapy (fotemustine and/or DTIC). To date, 12 patients have been treated. There was a complete remission of the brain metastases in four patients. In two patients a partial remission w...

journal_title：Journal of neuro-oncology

authors： Ulrich J,Gademann G,Gollnick H

更新日期：1999-06-01 00:00:00

abstract：:Pediatric glial tumors differ from adult gliomas in several ways that are of major therapeutic importance. First, the value of extensive tumor resection, which is controversial for malignant intrinsic brain tumors in adults, has been confirmed for a variety of childhood brain tumors, such as supratentorial high-grade ...

journal_title：Journal of neuro-oncology

authors： Pollack IF

更新日期：1999-05-01 00:00:00

abstract：:Topotecan was studied as a 72 h infusion given every 3 weeks. Treatment began at a dose of 1.0 mg/m2/day and was increased to 1.25 mg/m2/day after the first 6 patients tolerated this higher dose without excessive toxicities. Eighty-eight evaluable children were accrued in 6 strata. There were no complete nor partial r...

journal_title：Journal of neuro-oncology

authors： Kadota RP,Stewart CF,Horn M,Kuttesch JF Jr,Burger PC,Kepner JL,Kun LE,Friedman HS,Heideman RL

更新日期：1999-05-01 00:00:00

abstract：:Thrombin is known to play a role as regulator in tumor spreading and tumor growth. Proteinase-activated receptor 1 (PAR 1)-type thrombin receptors were identified in different cancer cells including human glioblastoma cells. Thus a function of PAR 1 in brain tumors may be suggested. In this study, the presence of PAR ...

journal_title：Journal of neuro-oncology

authors： Kaufmann R,Patt S,Kraft R,Zieger M,Henklein P,Neupert G,Nowak G

更新日期：1999-04-01 00:00:00

abstract：:We report the case of a 64 year old male patient with a history of ischemic heart disease who underwent surgery for an abdominal mass. The histological diagnosis was highly malignant non-Hodgkin's lymphoma. After surgery the patient was admitted to our Department and received 6 courses of chemotherapy according to the...

journal_title：Journal of neuro-oncology

authors： Merlo EM,Maiolo A,Brocchieri A,Tua A,Grignani G

更新日期：1999-03-01 00:00:00

abstract：:Cyclin-dependent kinase 4 inhibitor (CDKN2/p16) is a cell cycle regulatory protein that has been demonstrated to be inactivated by mutations, deletions or transcriptional silencing during pathogenesis of a variety of human malignancies. We studied the correlation of CDKN2/p16 expression with cell proliferation activit...

journal_title：Journal of neuro-oncology

authors： Miettinen H,Kononen J,Sallinen P,Alho H,Helen P,Helin H,Kalimo H,Paljärvi L,Isola J,Haapasalo H

更新日期：1999-02-01 00:00:00

abstract：:Pediatric brain gliomas are not always amenable for complete surgical excision, therefore adjuvant treatment for a large tumor mass is often required. As tumor volume shrinkage may not be a reliable method for assessing response to treatment, information about the tumor growth potential is desirable for an adequate fo...

journal_title：Journal of neuro-oncology

authors： Lazareff JA,Gupta RK,Alger J

更新日期：1999-02-01 00:00:00

abstract：:We report a case of high risk medulloblastoma with leptomeningeal intracranial and spinal metastasis in a 10-year-old girl treated successfully with conventional prolonged chemotherapy without radiotherapy. This is a particular case of medulloblastoma that at onset did not receive standard therapy for medulloblastoma ...

journal_title：Journal of neuro-oncology

authors： Schiavetti A,Varrasso G,Maurizi P,Trasimeni G,Carapella C,Castello MA

更新日期：1999-01-01 00:00:00

abstract：:A prospective pilot study was performed in order to assess the safety of treating recurrent malignant gliomas (MGs) with locally infused autologous tumor infiltrating lymphocytes (TILs) and recombinant interleukin-2 (rIL-2). Six patients were entered between June 27, 1994 and June 2, 1995 and followed until July 1, 19...

journal_title：Journal of neuro-oncology

authors： Quattrocchi KB,Miller CH,Cush S,Bernard SA,Dull ST,Smith M,Gudeman S,Varia MA

更新日期：1999-01-01 00:00:00

abstract：:Papillary meningioma is a rare subtype of meningioma that often behaves aggressively. In order to characterize factors that may influence this behavior, we chose to compare MIB-1 labeling index (LI) and telomerase RNA localization (hTR) in papillary meningiomas, meningiomas, and atypical meningiomas. LI is now often u...

journal_title：Journal of neuro-oncology

authors： Rushing EJ,Colvin SM,Gazdar A,Miura N,White CL 3rd,Coimbra C,Burns DK

更新日期：1999-01-01 00:00:00

abstract：:Neural cell adhesion molecule (NCAM) is down-regulated during periods of embryological cell migration and may be important in local tumor migration or metastases. Conflicting information exists in the literature about NCAM expression in human glial tumors and little is known about its expression in human brain metasta...

journal_title：Journal of neuro-oncology

authors： Kleinschmidt-DeMasters BK,Orr EA,Savelieva E,Owens GC,Kruse CA

更新日期：1999-01-01 00:00:00

abstract：:A major toxic effect of the chemotherapeutic agents paclitaxel and cisplatin is peripheral neuropathy. We report the use of a rat model of cytotoxic neuropathy to evaluate the role of glutamate as a possible neuroprotectant for these two drugs. Neuropathy was manifest as gait disturbance in 100% of paclitaxel treated ...

journal_title：Journal of neuro-oncology

authors： Boyle FM,Wheeler HR,Shenfield GM

更新日期：1999-01-01 00:00:00

abstract：:Human astrocytomas frequently co-express Fas (APO-1/CD95) and Fas ligand (FasL), yet do not appear to be overly susceptible to suicidal, fratricidal and immune-mediated elimination. This suggests that these gliomas have acquired mechanisms to prevent Fas-mediated apoptosis from occurring. Candidates for such a role in...

journal_title：Journal of neuro-oncology

authors： Frankel B,Longo SL,Ryken TC

更新日期：1999-01-01 00:00:00

abstract：:Central nervous system atypical teratoid/rhabdoid tumor (ATT/RT) of infancy and childhood is a unique histologic entity with an extremely aggressive natural history. Standard therapy for infant and childhood medulloblastoma, for which this entity is often mistaken, has been ineffective; most children survive less than...

journal_title：Journal of neuro-oncology

authors： Hilden JM,Watterson J,Longee DC,Moertel CL,Dunn ME,Kurtzberg J,Scheithauer BW

更新日期：1998-12-01 00:00:00

abstract：:Leiomyosarcoma has recently been identified as an AIDS-related tumor, usually occurring in children in the chest or abdomen. We describe a case of intracranial leiomyosarcoma in an adult with AIDS. An enhancing mass adjacent to the right occipital cortical surface was diagnosed during a work-up for left arm weakness. ...

journal_title：Journal of neuro-oncology

authors： Litofsky NS,Pihan G,Corvi F,Smith TW

更新日期：1998-11-01 00:00:00

abstract：:Four cases of intracranial osteosarcoma are reported. In three cases the tumors were primary neoplasms arising from the sellar region, base of the occiput and the parieto-occipital area. One case represented osteosarcoma metastatic to the cerebellum, a site not previously described, from a primary tumor at the femur. ...

journal_title：Journal of neuro-oncology

authors： Ashkan K,Pollock J,D'Arrigo C,Kitchen ND

更新日期：1998-10-01 00:00:00

abstract：:We have established a new xenogeneic animal model of leptomeningeal metastasis (LM) by intracisternal inoculation of human CEM T-cell lymphoma into nude rats, and used it to evaluate the anti-lymphoma efficacy of an anti-CD7 ricin A chain immunotoxin (DA7). In vitro incubation with 2 microg/ml DA7 for 72 h inhibited C...

journal_title：Journal of neuro-oncology

authors： Herrlinger U,Schmidberger H,Buchholz R,Wehrmann M,Vallera DA,Schabet M

更新日期：1998-10-01 00:00:00

abstract：:The new anticancer agent Taxol appears to potentiate the effects of radiation on brain tumor cell lines in vitro and was recently evaluated by our group as a radiosensitizer in a phase I study for primary brain tumors. In that study, we administered Taxol as a three-hour IV infusion repeated every week for six weeks a...

journal_title：Journal of neuro-oncology

authors： Wehbe T,Glantz M,Choy H,Glantz L,Cortez S,Akerley W 3rd,Mills P,Cole B

更新日期：1998-09-01 00:00:00